RB1 Antilichaam - N-terminalgebied: FITC (ARP58065 P050-FITC)

Retinoblastoma 1

RB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1

5925

P06400

NP_000312

Human, Mouse, Rat, Cow, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human RB1

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

RAF1; E2F1; ABL1; HDAC1; KDM2A; SMARCA4; USP7; UBC; DYRK1A; NEFM; DYRK1B; MAGEA11; ENC1; PPP1CA; CDKN1C; CDKN1A; CDK6; CDK4; CDK2; CCNE1; CCNA2; CCND1; HDAC11; PAX5; HIF1A; E2F4; CEBPE; CCNA1; SUMO1; UBE2I; TFAP2A; CDK3; CDK1; CCNC; CCNB1; MRPS18B; SUMO2

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

RB1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 93%; Human: 100%; Mouse: 80%; Pig: 93%; Rabbit: 93%; Rat: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

106kDa

Wet Ice

928

RB1

RB1

Rabbit

Retinoblastoma-associated protein

NM_000321

MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFE