RBBP8 Antilichaam - C-terminal regio: FITC (ARP50887_P050-FITC)

Retinoblastoma binding protein 8

RIM, COM1, CTIP, JWDS, SAE2, SCKL2

5932

A6NKN2

NP_976037

Human, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human RBBP8

RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

LMO4; PIN1; LMO1; MDM2; BRCA1; RBL1; TMEM54; PRRG4; RGS17; IKBKG; IGFBP7; EEF1A1; CTBP2; CLU; MAP2K4; RAF1; RBL2; PCNA; ZNF350; NBN; UIMC1; PALB2; BARD1; SPEN; RAD50; CTBP1; RB1; UBC; FXR2; RBBP8; IKZF1; LIMS1; SIAH2; SIAH1; LMO2; WDYHV1; ATM; TGIF2; IKZF

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 79%; Dog: 86%; Guinea Pig: 83%; Horse: 79%; Human: 100%; Pig: 100%; Rabbit: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

98kDa

Chen, L., (2008) J. Biol. Chem. 283 (12), 7713-7720

Wet Ice

867

RBBP8

RBBP8

Rabbit

DNA endonuclease RBBP8 Ensembl ENSP00000382630

NM_203292

ETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEE