RBM1-151

RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 , as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em). RBM1-151 is hydrolyzed by acid ceramidase (AC) ((appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase (appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) (appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer)[2].

3077081-47-8

12352005

Ceramidase; Fluorescent Dye

Metabolic Enzyme/Protease; Others

Cancer-programmed cell death

Cancer

CCCCCCCCCCCC(N[C@@H](C)[C@H](O)C/C=C/COC1=CC=C(C=CC(O2)=O)C2=C1)=O

C28H41NO5

471.63

[1]Casasampere M, et al. A fluorogenic substrate for the detection of lipid amidases in intact cells. J Lipid Res. 2024 Mar;65 (3) :100520. |[2]Ciuffreda P, et al. Fluorescence-Based Enzyme Activity Assay: Ascertaining the Activity and Inhibition of Endocannabinoid Hydrolytic Enzymes. Int J Mol Sci. 2024 Jul 13;25 (14) :7693.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15826/

Natural Products

No Development Reported