RC3H1 Antilichaam

RC3H1 Antibody: The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.

149041

Q5TC82

NP_742068

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

RC3H1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

RC3H1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RC3H1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

125 kDa

IgG

At least three isoforms of RC3H1 are known to exist; this antibody will detect all three isoforms.

RC3H1

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Ring finger and CCCH-type domains 1

Homo sapiens

Vinuesa CG, Cook MC, Angelucci C, et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005; 435:452-8.

Bertossi A, Aichinger M, Sansonetti P, et al. Loss of Roquin induces immune deregulation but not autoimmunity. J. Exp. Med. 2011; 208:1749-56.

RC3H1 Antibody: RNF198, ROQUIN, KIAA2025, RNF198, Roquin-1, RING finger and C3H zinc finger protein 1, Roquin

ELISA, WB, IHC-P, IF

73695473

Liquid