Recombinant ATG9A Monoklonale Antilichaam

ATG9A are lipid scramblases that play a role in autophagosome expansion. ATG9A is present in numerous intracellular compartments, including the trans-Golgi network and early and recycling endosomes, and traffics through the secretory pathway to the plasma membrane and to the endocytic pathway from the plasma membrane. ATG9A protects cells against plasma membrane damage caused by a spectrum of exogenous and endogenous agents, including permeabilization by gasdermin and mixed lineage kinase domain like (MLKL), which generate pores at the plasma membrane or perturb plasma membrane integrity, respectively, during programmed cell death processes of pyroptosis and necroptosis. We furthermore define the ATG9A–IQGAP1 apparatus that integrates with the ESCRT system to cooperatively heal areas of plasma membrane damage.

ATG9A

Q7Z3C6

Human

Recombinant human ATG9A fragment

MGD; mATG; APG9L; ATG9A; APG9L1; MGD3208; mATG9; APG9 autophagy 9-like 1; APG9 like 1; APG9-like 1; ATG9; ATG9 autophagy related 9 homolog A; ATG9 autophagy related 9 homolog A (S. cerevisiae) ; Autophagy 9-like 1 protein; Autophagy related 9A; Autophagy related protein 9A; Autophagy-related protein 9A; OTTHUMP00000206046; OTTHUMP00000206048; OTTHUMP00000206049; OTTHUMP00000206062

A507

Unconjugated

WB; IHC; IF; FCM

Cell Biology; Neuroscience; Cancer; Cardiovascular; Metabolism

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:50-1:100; IF 1:50; FCM 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/7LZv2hh3

94 kDa

100 kDa

IgG, κ