Recombinant ATP Citrate Lyase Monoklonale Antilichaam

ATP-citrate lyase (ACL) is a homotetramer that catalyzes the formation of acetyl-CoA and oxaloacetate (OAA) in the cytosol, which is the keystep for the biosynthesis of fatty acids, cholesterol and acetylcholine, as well as for glucogenesis. Nutrients and hormones regulate theexpression level and phosphorylation of ATP-citrate lyase. It is phosphorylated by GSK-3 on Thr446 and Ser450. Ser455 of ATP-citrate lyasehas been reported to be phosphorylated by PKA and Akt. Phosphorylation on Ser455 abolishes the homotropic allosteric regulation by citrateand enhances the catalytic activity of the enzyme.

ATP Citrate Lyase

P53396

Human; Rat; Mouse

Peptide. This information is proprietary to PTMab.

OTTHUMP; ACLY; ACL; ATPCL; CLATP; ATP citrate (pro-S) lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate (pro-S-) -lyase; ATPcitrate synthase; ATP-citrate synthase; Citrate cleavage enzyme; OTTHUMP00000164773

A772

Unconjugated

WB; IHC

Signal Transduction; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:500

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/oSoZqzWB

120 kDa

125 kDa

IgG, κ