Recombinant B7-H3-eiwit van muizen

B7H3, also known as CD276 antigen, is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. This protein plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. It induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. Recombinant mouse B7H3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD276 antigen, Cd276, 6030411F23Rik, AU016588, B7h3, B7RP-2, B7 homolog 3, B7-H3

Baculovirus

Mouse

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

24.7 kDa (226aa)

B7-H3, ATGP3890-10 µg, ATGP3890-20 µg, ATGP3890-50 µg, ATGP3890-100 µg, ATGP3890-250 µg, ATGP3890-500 µg, ATGP3890-1 mg, ATGP3890-10, ATGP3890-20, ATGP3890-50, ATGP3890-100, ATGP3890-250, ATGP3890-500, ATGP3890-1, ATGP3890-10 µg, ATGP3890-20 µg, ATGP3890-50 µg, ATGP3890-100 µg, ATGP3890-250 µg, ATGP3890-500 µg, ATGP3890-1 mg, ATGP3890-10, ATGP3890-20, ATGP3890-50, ATGP3890-100, ATGP3890-250, ATGP3890-500, ATGP3890-1

Wang Z., et al. (2018) Cancer Sci. 109:2697-2705.; ; Son Y., et al. (2019) Stem Cells. 37:382-394.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_598744

Q8VE98

Mouse

Val29