Recombinant Bmi-1 Monoklonale antilichamen

BMI1 proto-oncogene, polycomb ring finger (BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1) . This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Bmi-1

P35226

Human; Mouse; Rat

Recombinant Human Bmi-1 protein

RNF; BMI; PCGF; flvi-2/bmi; FLVI2/BMI; BMI1; FLVI2/BMI1; PCGF4; RNF51; flvi-2/bmi-1; Bmi-1

7B9

Unconjugated

IHC

Cell Biology; Epigenetics and Nuclear Signaling; Stem Cells; Cancer

Protein A

0.2 mg/mL

IHC 1:100-1:500

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/UZz7wMWO

IgG, κ