Recombinant Caveoline-3 Monoklonale Antilichaam

The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease. Caveolins interact with multiple signaling molecules, such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7. Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway.

Caveolin-3

P56539

Human; Rat; Mouse

Recombinant human Caveolin-3 fragment

LQT; CAV; VIP; CAV3; LGMD1C; LQT9; VIP-21; VIP21; Caveolin 3; Caveolin-3; M-caveolin; MGC126100; MGC126101; MGC126129; OTTHUMP00000115603; OTTHUMP00000207105; VIP 21

A631

Unconjugated

WB; IHC

Signal Transduction; Tags & Cell Markers; Cardiovascular; Developmental Biology

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:100-1:400

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/FMDlqsoM

17 kDa

17 kDa

IgG, κ