Recombinant CD8 beta Monoklonale Antilichaam

Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC) . Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation.

CD8 beta

P10966

Mouse

Peptide. This information is proprietary to PTMab.

LYT; LEU; CD8B; CD8B1; LEU2; LY3; LYT3; P37; T-Cell Surface Glycoprotein CD8 Beta Chain; CD8; Lyt3

A702

Unconjugated

WB; IHC

Immunology

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/QO82WcmN

24 kDa

28-32 kDa

IgG, κ