Recombinant CENP-A Monoklonale Antilichaam

Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore .The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3.May serve as an epigenetic mark that propagates centromere identity through replication and cell division.Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.

CENP-A

P49450

Human; Rat; Mouse

Recombinant human CENP-A fragment

CenH; CENPA; CENP-A; CenH3

A184

Unconjugated

WB; IHC; IF; FCM

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:2000; IHC 1:100-1:1000; IF 1:50; FCM 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/9TxLx0Bx

16 kDa

18 kDa

IgG, κ