Recombinant CPT1B Monoklonale Antilichaam

Carnitine palmitoyltransferase-1 (CPT1), localized to the mitochondrial outer membrane, translocates fatty acids across the mitochondrial membranes and catalyzes the rate-limiting step of β-oxidation. There are three isoforms of this enzyme: CPT1A (liver), CPT1B (muscle), and CPT1C (brain) . Deficiency of CPT1A results in an autosomal recessive mitochondrial fatty acid oxidation disorder. Studies have shown that physiological high blood glucose and insulin levels inhibit CPT1B activity in human muscle and therefore divert long-chain fatty acids toward storage in human muscle as triglycerides. Furthermore, mice deficient in CPT1C show less food intake and reduced body weight. These findings suggest that CPT1 may play a role in metabolic syndromes.

CPT1B

Q92523

Human

Recombinant human CPT1B fragment

KIAA; KIAA1670; CPT1B; CPT I; CPT1-M; CPTI-M

A672

Unconjugated

WB; IHC

Signal Transduction; Cardiovascular; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:1000-1:5000; IHC 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/pxJ7aKYv

87 kDa

87 kDa

IgG, κ