Recombinant E-Cadherine/CDH1/E-cad/CD324 Monoclonaal antilichaam

Epithelial (E) - Cadherin (ECAD), also known as cell-CAM120/80 in the human, uvomorulin in the mouse, Arc-1 in the dog, and L-CAM in the chicken, is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin) . This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. E‑Cadherin contains five extracellular calcium-binding domains of approximately 110 amino acids each.

CDH1

P12830

Human

Recombinant Human E-Cadherin / CDH1 / E-cad / CD324 Protein

CDH; Arc; CADH; CD antigen CD; Cleaved into: E-Cad/CTF; Cadherin; CAM 120/; Arc-1; CD324; CDHE; ECAD; LCAM; UVO; CDH1; E-Cadherin; CADH1; Cadherin-1; Uvomorulin; E-Cad; CTF2; CAM 120/80; Epithelial cadherin; CD antigen CD324; Cleaved into: E-Cad/CTF1; CTF3; CDH1; Arc 1; Arc 1; CADH1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 324; CD324; CD324 antigen; cdh1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin; Arc-1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CD 324; CD324 antigen; E-Cad/CTF3; epithelial calcium dependant adhesion protein; Liver cell adhesion molecule

6C9

Unconjugated

WB; IP

Signal Transduction; Cancer; Developmental Biology; Tags & Cell Markers

Protein A

1 mg/mL

WB 1:500-1:2000; IP 4-8 μL/mg of lysate

0.2 μm filtered solution in PBS

Ice bag

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

https://789.bio/eb/XmvbYpuL

97 kDa

130 kDa

IgG