Recombinant E2F-1 monoklonaal antilichaam

The protein encoded by this gene is a member ofThe E2F family of transcription factors.The E2F family plays a crucial role inThe control of cell cycle and action of tumor suppressor proteins and is also a target ofThe transforming proteins of small DNA tumor viruses.The E2F proteins contain several evolutionally conserved domains found in most members ofThe family. These domains include a DNA binding domain, a dimerization domain which determines interaction withThe differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded withinThe transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.

E2F-1

Q01094

Human; Mouse; Rat

Recombinant Human E2F-1 protein

RBP; RBAP; RBBP; E2F; E2F-1; RBAP1; RBBP3; RBP3; E2F1

5F4

Unconjugated

WB

Epigenetics and Nuclear Signaling; Cancer

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/p2SfO3Hz

47 kDa

60 kDa

IgG, κ