Recombinant eIF4G1 monoklonaal antilichaam

The initiation of translation is an important biological event and a variety of factors contribute to this process. Members of the eIF4 translation initiation factor family bind to the 5' m7GTP mRNA cap and unwind the mRNA secondary structure. The amino-terminal portion of eIF4G physically associates with eIF4E to stimulate the binding of eIF4E to the mRNA cap structure. eIF4G also interacts with eIF3 and eIF4A and serves as an adaptor molecule in the eIF4 complex. Moreover, eIF4G plays a role in internal ribosomal entry site (IRES) -mediated initiation of translation. The eIF4G family includes eIF4G1 (eIF4GI), eIF4G2 (p97, DAP5 or NAT1), and eIF4G3 (eIF4GII) . These factors share a homologous sequence that provides for interaction with initiation factors eIF3 and eIF4A. Both eIF4G1 and eIF4G3 are involved in cap-dependent translation, while eIF4G2 plays a role in IRES-mediated translation of some genes during cell stress.

EIF4G1

Q04637

Human; Mouse

Recombinant human eIF4G1 fragment

PARK; DKFZp686A; eIF 4 gamma; eIF-4-gamma; Eukaryotic translation initiation factor 4 gamma; IF4G; EIF4G1; EIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18; DKFZp686A1451; eIF 4 gamma 1; eIF 4G 1; eIF 4G1; EIF4 gamma; eIF-4G 1; eIF-4-gamma 1; Eukaryotic translation initiation factor 4 gamma 1; IF4G1

A669

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:500-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/DEECFhjh

175 kDa

250 kDa

IgG, κ