Recombinant ENPP1 / pc1 monoklonaal antilichaam

Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di leucine-based signal. ENPP1 plays important roles in bone mineralization and soft tissue calcification. Mutations in the corresponding ENPP1 gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) . ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice. Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes.

ENPP1/PC1

P22413

Human

Peptide. This information is proprietary to PTMab.

M6S; PDNP; Enpp; M6S1; NPPS; PC1; PDNP1; ENPP1

A714

Unconjugated

WB; IHC

Signal Transduction; Cell Biology; Metabolism; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:2000-1:5000; IHC 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/w7A5GcCe

105 kDa

130 kDa

IgG, κ