Recombinant ErbB3/HER3 Monoklonale antilichamen

HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins, and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase. There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2, and the p85 subunit of PI3 kinase, which mediate ErbB downstream signaling. Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3K.

ErbB3/HER3

P21860

Human; Rat

Recombinant human ErbB3 / HER3 fragment

HER; LCCS; Proto-oncogene-like protein c-ErbB; Tyrosine kinase-type cell surface receptor HER; MDA-BF; p180-ErbB; p45-sErbB; p85-sErbB; ERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; EEBB3

A539

Unconjugated

WB

Signal Transduction; Cancer

Protein A purified

1 mg/mL

WB 1:500-1:2000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/tMj3kWH5

148 / 77 kDa

185 / 98 kDa

IgG, κ