Recombinant fosfor-EGFR (Tyr1173) Monoklonale antilichamen

The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand bindingresults in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation.Phosphorylation of EGF receptor (EGFR) at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the activestate enzyme, and providing a binding surface for substrate proteins. c-Src is involved in phosphorylation of EGFR at Tyr845. The SH2 domainof PLCγ binds at phospho-Tyr992, resulting in activation of PLCγ-mediated downstream signaling. Phosphorylation of EGFR at Tyr1045creates a major docking site for the adaptor protein c-Cbl, leading to receptor ubiquitination and degradation following EGFR activation. TheGRB2 adaptor protein binds activated EGFR at phospho-Tyr1068. A pair of phosphorylated EGFR residues (Tyr1148 and Tyr1173) provide adocking site for the Shc scaffold protein, with both sites involved in MAP kinase signaling activation. Phosphorylation of EGFR at specificserine and threonine residues attenuates EGFR kinase activity. EGFR carboxy-terminal residues Ser1046 and Ser1047 are phosphorylatedby CaM kinase II; mutation of either of these serines results in upregulated EGFR tyrosine autophosphorylation.

Phospho-EGFR (Tyr1173)

P00533

Human

Peptide. This information is proprietary to PTMab

PIG; HER; Proto-oncogene c-ErbB; Receptortyrosine-protein kinase erbB; Receptor tyrosine-protein kinase erbB; NISBD; EGFR; ERBB; ERBB1; HER1; NISBD2; PIG61; mENA; ErbB-1; Receptortyrosine-protein kinase erbB-1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; NISBD2; epidermal growth factor receptor; ERBB; ERBB1; HER1; mENA; NISBD2; PIG61; Avian erythroblastic leukemia viral (v erb b) oncogene homolog; Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) ; Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) ; ErbB1; ERBB; erb-b2 receptor tyrosine kinase 1; Errp; Oncogen ERBB; Receptor tyrosine protein kinase ErbB 1; SA7; Species antigen 7; Urogastrone; v-erb-b Avian erythroblastic leukemia viral oncogen homolog; wa2; Wa5

A825

Unconjugated

WB; IF

Signal Transduction; Cancer

Protein A purified

1 mg/mL

WB 1:1000; IF 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/I3S85E7V

134 kDa

170 kDa

IgG, κ