Recombinant fosfor-ErbB-3 (Tyr1289) Monoklonale antilichamen

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell.

ErbB-3

P21860

Human; Mouse; Rat

A synthetic peptide corresponding to residues around (Tyr1289) of Human Phospho-ErbB-3

HER; LCCS; Proto-oncogene-like protein c-ErbB; Tyrosine kinase-type cell surface receptor HER; MDA-BF; p180-ErbB; p45-sErbB; p85-sErbB; ERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; EEBB3; ErbB-3/her2

11A5

Unconjugated

WB

Signal Transduction; Cancer

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/XUNJJghw

148 kDa

185 kDa

IgG, κ