Recombinant fosfor-PDPK1 (Ser241) Monoclonaal antilichaam

ATP + a protein = ADP + a phosphoprotein., Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity) . Isoform 3 is catalytically inactive., PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily., similarity:Contains 1 PH domain., similarity:Contains 1 protein kinase domain., subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane., subunit:Interacts with TUSC4., tissue specificity:Appears to be expressed ubiquitously.

PDPK1

O15530

Human; Mouse; Rat

A synthetic peptide corresponding to residues around (Ser241) of Human Phospho-PDPK1

PDK; PRO;3-phosphoinositide-dependent protein kinase; PDPK1; PDK1; PDPK2; PDPK2P; PRO0461;3-phosphoinositide-dependent protein kinase 1;3-phosphoinositide-dependent protein kinase 1; PDK1; PDPK2; PDPK2P; PRO0461;3 phosphoinositide dependent protein kinase 1; hPDK 1; hPDK1; MGC20087; MGC35290; OTTHUMP00000159109; OTTHUMP00000159110; OTTHUMP00000174525; PkB kinase; PkB kinase like gene 1; PkB like 1; Protein kinase

7C9

Unconjugated

WB

Signal Transduction

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/n44fm4wu

63 kDa

63 kDa

IgG, κ