Recombinant Gelsoline Monoklonale Antilichaam

Gelsolin shares structural and functional homology to villin and adseverin/scinderin. It plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner. Gelsolin is important for cellular events that require cytoskeletal remodeling. Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation. In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition.

Gelsolin

P06396

Human

Recombinant human Gelsolin fragment

DKFZp313L; GSN; ADF; AGEL; gelsolin; Actin depolymerizing factor; DKFZp313L0718; Brevin; GELS; Actin-depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; GELS; GSN

A536

Unconjugated

WB; IF; FCM

Signal Transduction

Protein A purified

1 mg/mL

WB 1:500-1:2000; IF 1:50; FCM 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/Erawymdd

81 kDa

81 kDa

IgG, κ