Recombinant GLUT3 + GLUT14 monoklonaal antilichaam

A group of related glucose transporters (Glut1-5 and 7) mediate the facilitated diffusion of glucose in nonepithelial mammalian tissues. Glucose transporter 3 (Glut3), also known as SLC2A3, has a higher affinity for glucose than the ubiquitous glucose transporter Glut1. In the normal brain, Glut3 expression is limited to neurons, whereas Glut1 is expressed in both neurons and glia. Glioblastoma-derived brain tumor initiating cells (BTICs) express increased levels of Glut3, enabling their survival in the microenvironment deficient in glucose. In addition, Glut3 expression levels correlate with poor survival in brain tumors. Glucose transporter 4 (Glut4) is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation. Translocation of Glut4 is dependent on Akt, which may act by phosphorylating AS160, a RabGAP protein involved in membrane trafficking.The antibody can detect both GLUT3 and GLUT4.

GLUT3+GLUT14

P11169

Human; Rat

Recombinant human GLUT3+GLUT14 fragment

GTR; Solute carrier family; Glucose transporter type; facilitated glucose transporter member; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member; SLC2A; SLC2A3; GLUT3; facilitated glucose transporter member 3; FLJ90380; Glucose transporter type 3; Glucose transporter type 3 brain; GLUT 3; GLUT-3; GTR3; Solute carrier family 2; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3; brain

A645

Unconjugated

WB

Signal Transduction; Cell Biology; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/PzLafNXP

54 kDa

54 kDa

IgG, κ