Recombinant humaan 2B4/CD244 eiwit

CD244, also known as natural killer cell receptor 2B4 isoform 1, is a natural killer and T cell immunoglobulin superfamily surface protein and ligand of CD48. It is a cell surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T lymphocyte function. It is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. It activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness. Recombinant human CD244, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Human CD48/SLAMF2 (CAT# ATGP3642) is coated at 2 µg/mL (100 ul/well) can bind Human CD244. The ED50 range ≤ 0.1 µg/mL.

CD244 molecule natural killer cell receptor 2B4, NAIL, NKR2B4, Nmrk, SLAMF4

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE, Bioactivity

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

Measured by its binding ability in a functional ELISA with Human CD48/SLAMF2 (CAT# ATGP3642) . The ED50 range ≤ 0.1 µg/mL.

50.2 kDa (448aa)

SLAMF4, Nmrk, NKR2B4, Natural killer cell receptor 2B4 isoform 1, natural killer cell receptor 2B4, NAIL, CD244 molecule natural killer cell receptor 2B4, CD244 molecule, CD244, 2B4, ATGP3552-10 µg, ATGP3552-20 µg, ATGP3552-50 µg, ATGP3552-100 µg, ATGP3552-250 µg, ATGP3552-500 µg, ATGP3552-1 mg, ATGP3552-010, ATGP3552-020, ATGP3552-050, ATGP3552-100, ATGP3552-250, ATGP3552-500, ATGP3552-01M

Brown MH., et al. (1998) J Exp Med. 188:2083-2090.; ; Chuang SS., et al. (2001) J Immunol. 167:6210-6216.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_057466.1

Q9BZW8

Human

Ala

GKGCQGS ADHVVSISGV PLQLQPNSIQ TKVDSIAWKK LLPSQNGFHH ILKWENGSLP SNTSNDRFSF IVKNLSLLIK AAQQQDSGLY CLEVTSISGK VQTATFQVFV FDKVEKPRLQ GQGKILDRGR CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN VSNPVSWESH TLNLTQDCQN AHQEFRFWP