Recombinant humaan ABP1/AOC1-eiwit

ABP1, also known as diamine oxidase (DAO) and amine oxidase copper domain-containing protein 1 (AOC1), is a member of the copper-containing amine oxidase family. This enzyme catalyzes the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. It has an important role in the catabolism of histamine and other bioactive polyamines. Deficiencies in ABP1 can result in histaminosis or dietary histamine intolerance. This protein is also contributed to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer. Recombinant human AOC1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Amiloride-sensitive amine oxidase, DAO, Diamine oxidase, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, KAO, ABP, ABP1, DAO1

HEK293

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

84.2kDa (738aa)

, ATGP3938-10 µg, ATGP3938-20 µg, ATGP3938-50 µg, ATGP3938-100 µg, ATGP3938-250 µg, ATGP3938-500 µg, ATGP3938-1 mg, ATGP3938-10, ATGP3938-20, ATGP3938-50, ATGP3938-100, ATGP3938-250, ATGP3938-500, ATGP3938-1

Novotny, W.F. et al. (1994) J. Biol. Chem. 269:9921-9925.; ; Jones, B.L. and G.L. Kearns (2011) Clin. Pharmacol. Ther. 89:189-197.; ; Bieganski, T. et al. (1983) Biochim. Biophys. Acta 756:196-203.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001082

P19801

Human

Glu19