Recombinant humaan ACBP/DBI-eiwit

ACBP, also known as ACBD1, is a diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. Expression of ACBP is significantly induced during adipocyte differentiation. ACBP is a target for proliferator-activated receptor (PPAR) gamma, and is directly activated by PPARgamma/RXRalpha and PPARalpha/RXRalpha, but not by PPARdelta/RXRalpha. Recombinant human ACBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Acyl-CoA-binding protein, ACBD1, CCK-RP, EP, DBI, Acyl-CoA-binding protein, Diazepam Binding Inhibitor Protein, GABA receptor modulator, Acyl-Coenzyme A binding protein, Endozepine

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

12.2 kDa (107aa) confirmed by MALDI-TOF

ACBP, Acyl-CoA-binding protein, ACBD1, CCK-RP, EP, DBI, Acyl-CoA-binding protein, Diazepam Binding Inhibitor Protein, ATGP0567-10 µg, ATGP0567-20 µg, ATGP0567-50 µg, ATGP0567-100 µg, ATGP0567-250 µg, ATGP0567-500 µg, ATGP0567-1 mg, ATGP0567-10, ATGP0567-20, ATGP0567-50, ATGP0567-100, ATGP0567-250, ATGP0567-500, ATGP0567-1

Folli F., et al. (2010) PLoS One. 5 (3) :e9923. ; ; Manjithaya R., et al. (2010) J Cell Biol. 188 (4) :537-46.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol

Neuroscience

NP_001073331

P07108

Human

MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI