Recombinant humaan Activine-RIA/ALK-2-eiwit

Activin RIA, also known as Activin receptor type-1, is a member of TGF-beta serine/threonine kinase receptor family. It forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. This protein is involved for left-right pattern formation during embryogenesis. Also, it is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. It has been connected to Fibrodysplasia Ossificans Progressiva, a disease characterized by the formation of heterotopic bone throughout the body. Recombinant Human Activin RIA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

ACVR1, ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI, Activin receptor type I, Activin receptor-like kinase 2, ACTR-I, ALK-2, TSR-I, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

38.4 kDa (342aa)

Activin RIA, ALK2, ATGP3898-10 µg, ATGP3898-20 µg, ATGP3898-50 µg, ATGP3898-100 µg, ATGP3898-250 µg, ATGP3898-500 µg, ATGP3898-1 mg, ATGP3898-10, ATGP3898-20, ATGP3898-50, ATGP3898-100, ATGP3898-250, ATGP3898-500, ATGP3898-1, ATGP3898-10 µg, ATGP3898-20 µg, ATGP3898-50 µg, ATGP3898-100 µg, ATGP3898-250 µg, ATGP3898-500 µg, ATGP3898-1 mg, ATGP3898-10, ATGP3898-20, ATGP3898-50, ATGP3898-100, ATGP3898-250, ATGP3898-500, ATGP3898-1

Sorkin M., et al. (2017) Wound Repair Regen. 25:521-525.; ; Schoenmaker T., et al. (2019) J Cell Physiol. 234:10238-10247.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Cytoskeleton

NP_001096

Q04771

Human

Met21