Recombinant humaan Adiponectrip30-eiwit

Human Adiponectin, also referred to as AdipoQ, Acrp30, apm-1 or GBP28, is a secreted protein expressed exclusively in differentiated adipocyte (adipokine) . Adiponectin contains a modular structure comprising an N-terminal collagenous domain followed by a C-terminal globular domain. Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia.

ADIPOQ, ACDC, ACRP30, APM1, GBP28, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein

E.coli

Human

Non-Tagged

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

25.1 kDa (231aa)

Adiponectin, Acrp30, ADI0501-10 µg, ADI0501-20 µg, ADI0501-50 µg, ADI0501-100 µg, ADI0501-250 µg, ADI0501-500 µg, ADI0501-1 mg, ADI0501-10, ADI0501-20, ADI0501-50, ADI0501-100, ADI0501-250, ADI0501-500, ADI0501-1

Maeda K., et al. (1996) Biochem Biophys Res Commun. 221:286-9.; ; Berg AH., et al. (2001) Nat Med. 7:947-53; ; Berg AH., et al. (2002) Trends Endocrinol Metab. 13: 84-89.; ; Yamauchi T et al., (2002) Nat Med. 8:1288-95;

Jung TW, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. (Biochem Pharmacol. 2006) {https://pubmed.ncbi.nlm.nih.gov/16814256/}; ; Jung TW, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. (Biochem Biophys Res Commun. 2006) {https://pubmed.ncbi.nlm.nih.gov/16554029/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT

Hormones & Cytokines

NP_004788.1

Q15848

Human

MGHDQETTTQ GPGVLLPLPK GACTGWMAGI PGHPGHNGAP GRDGRDGTPG EKGEKGDPGL IGPKGDIGET GVPGAEGPRG FPGIQGRKGE PGEGAYVYRS AFSVGLETYV TIPNMPIRFT KIFYNQQNHY DGSTGKFHCN IPGLYYFAYH ITVYMKDVKV SLFKKDKAML FTYDQYQENN VDQASGSVLL HLEVGDQVWL QVYGEGERNG LYADNDNDST FTGFLLYHDT N