Recombinant humaan ALK-3/BMPR1A-eiwit

BMPR1A, also known as bone morphogenetic protein receptor type-1A, is secreted cytokines/growth factors belonging to the Transforming Growth Factor beta (TGFbeta) family. It has been shown to be overexpressed in human breast cancers. Its deletion impairs mammary tumor formation and metastasis. It plays important roles in the differentiation and development of neurons. Its expression is up-regulated during bone formation, and that they may play important roles in bone morphogenesis. Recombinant human BMPR1A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Bone morphogenetic protein receptor type 1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, ACVRLK3, ALK3

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

41.4 kDa (371aa)

BMPR-IA, ALK3, Bone morphogenetic protein receptor type-1A, BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, ATGP3541-10 µg, ATGP3541-20 µg, ATGP3541-50 µg, ATGP3541-100 µg, ATGP3541-250 µg, ATGP3541-500 µg, ATGP3541-1 mg, ATGP3541-10, ATGP3541-20, ATGP3541-50, ATGP3541-100, ATGP3541-250, ATGP3541-500, ATGP3541-1

Pickup MW., et al. (2015) Oncotarget. 6:22890-22904.; ; Wang W., et al. (2014) Int J Clin Exp Pathol. 7:2312-2318.; ; Ishidou Y., et al. (1995) J Bone Miner Res. 10:1651-1659.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_004320

P36894

Human

Ala

ADPQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H