Recombinant humaan Angiopoëtine-achtig 3/ANGPTL3-eiwit

ANGPTL3 also known as Angiopoietin-related protein 3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN) -like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Recombinant human ANGPTL3, fused to His-tag at N-terminus, was expressed in E. coli.

ANG-5, Angiopoietin 5, Angiopoietin-related protein 3, ANGPT5, ANGPTL3, ANL3, FHBL2

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

27.7 kDa (239aa)

Angiopoietin-like3, Angiopoietin-related protein 3, ANG-5, ANGPT5, ANL3, FHBL2, ATGP3149-10 µg, ATGP3149-20 µg, ATGP3149-50 µg, ATGP3149-100 µg, ATGP3149-250 µg, ATGP3149-500 µg, ATGP3149-1 mg, ATGP3149-10, ATGP3149-20, ATGP3149-50, ATGP3149-100, ATGP3149-250, ATGP3149-500, ATGP3149-1

Arca M., et al. (2013) Curr. Opin. Lipidol. 24 (4) :313-20; ; Quagliarini F Q., et al. (2012) Proc Natl Acad Sci. 109 (48) :19751-6

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Apoptosis

NP_055310

Q9Y5C1

Human

MGSSHHHHHH SSGLVPRGSH MPAECTTIYN RGEHTSGMYA IRPSNSQVFH VYCDVISGSP WTLIQHRIDG SQNFNETWEN YKYGFGRLDG EFWLGLEKIY SIVKQSNYVL RIELEDWKDN KHYIEYSFYL GNHETNYTLH LVAITGNVPN AIPENKDLVF STWDHKAKGH FNCPEGYSGG WWWHDECGEN NLNGKYNKPR AKSKPERRRG LSWKSQNGRL YSIKSTKMLI HPTDSESFE