Recombinant humaan Apolipoproteïne M/APOM-eiwit

Apolipoproteins are protein components of plasma lipoproteins. APOM is a member of the lipocalin family of proteins. APOM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. APOM is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. It is important for the formation of prebeta-HDL and cholesterol efflux to HDL, and thereby inhibits formation of atherosclerotic lesions. The concentration of APOM in plasma strongly correlates with total cholesterol. Low concentrations of APOM in plasma are associated with diabetes. Recombinant human APOM protein was expressed in E. coli and purified by using conventional chromatography techniques.

Apolipoprotein M, G3a, HSPC336, NG20, Apolipoprotein M Apo M, ApoM, G3A, MGC22400, NG20 like protein, Protein G3a.

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

20.9 kDa (187aa) confirmed by MALDI-TOF

Apolipoprotein M, ApoM, Apolipoprotein M, G3a, HSPC336, NG20, Apolipoprotein M Apo M, ApoM, G3A, MGC22400, NG20 like protein, Protein G3a., ATGP0521-10 µg, ATGP0521-20 µg, ATGP0521-50 µg, ATGP0521-100 µg, ATGP0521-250 µg, ATGP0521-500 µg, ATGP0521-1 mg, ATGP0521-10, ATGP0521-20, ATGP0521-50, ATGP0521-100, ATGP0521-250, ATGP0521-500, ATGP0521-1

Jiang J., et al. (2008) Lipids Health Dis. 7:25. ; ; Duan J., et al. (2001) FEBS Lett. 499 (1-2) :127-32. ;

Takahashi C, et al. Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. (J Atheroscler Thromb. 2017) {https://pubmed.ncbi.nlm.nih.gov/28321011/}; ; Kurano M, et al. Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. (Biochim Biophys Acta. 2014) {https://pubmed.ncbi.nlm.nih.gov/24814049/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Adhesion & Movement

NP_061974

O95445

Human

MGSSHHHHHH SSGLVPRGSH MCPEHSQLTT LGVDGKEFPE VHLGQWYFIA GAAPTKEELA TFDPVDNIVF NMAAGSAPMQ LHLRATIRMK DGLCVPRKWI YHLTEGSTDL RTEGRPDMKT ELFSSSCPGG IMLNETGQGY QRFLLYNRSP HPPEKCVEEF KSLTSCLDSK AFLLTPRNQE ACELSNN