Recombinant humaan ARLTS1/ARL11-eiwit

ARL11 (ADP-ribosylation factor-like protein 11), is a member of the ARF family of the Ras superfamily of small GTPases that are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD) . ARL11 is thought to function as a tumor suppressor that may play a role in the regulation of apoptosis. Recombinant human ARL11 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

ADP-ribosylation factor-like 11, ARLTS1, ADP ribosylation factor like GTPase 11, ADP-ribosylation factor-like tumor suppressor gene 1

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

23.6 kDa (216aa) confirmed by MALDI-TOF

ARL11, ADP-ribosylation factor-like 11, ARLTS1, ATGP1130-10 µg, ATGP1130-20 µg, ATGP1130-50 µg, ATGP1130-100 µg, ATGP1130-250 µg, ATGP1130-500 µg, ATGP1130-1 mg, ATGP1130-10, ATGP1130-20, ATGP1130-50, ATGP1130-100, ATGP1130-250, ATGP1130-500, ATGP1130-1

Yendamuri S., et al (2008) Cancer Lett. 264 (1) :11-20. ; ; Calin G.A., et al (2005) N. Engl. J. Med. 352:1667-1676.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 30% glycerol, 100 mM NaCl, 1mM EDTA

Cancer

NP_612459

Q969Q4

Human

MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS