Recombinant humaan ATF4-eiwit

Activating transcription factor 4, also known as ATF4, belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins and CREB-like proteins. ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. Recombinant human ATF4 protein, fused to His-Calmodulin tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Activating transcription factor 4, CREB2, TXREB, CREB-2

E.coli

Human

His-Cam Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

56.6 kDa (510aa)

ATF4, ATGP1138-10 µg, ATGP1138-20 µg, ATGP1138-50 µg, ATGP1138-100 µg, ATGP1138-250 µg, ATGP1138-500 µg, ATGP1138-1 mg, ATGP1138-10, ATGP1138-20, ATGP1138-50, ATGP1138-100, ATGP1138-250, ATGP1138-500, ATGP1138-1

Lin Y S., et al. (1988) Proc Natl Acad Sci. 85:3396-4000.; ; Hoeffler JP., et al. (1988) Science. 242:1430-1433.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Signal Transduction

NP_001666

P18848

Human

M TEMSFLSSEV LVGDLMSPFD QSGLGAEESL GLLDDYLEVA KHFKPHGFSS DKAKAGSSEW LAVDGLVSPS NNSKEDAFSG TDWMLEKMDL KEFDLDALLG IDDLETMPDD LLTTLDDTCD LFAPLVQETN KQPPQTVNPI GHLPESLTKP DQVAPFTFLQ PLPLSPGVLS STPDHSFSLE LGSEVDITEG DRKPDYTAYV AMIPQCIKEE DTPSDNDSGI CMSPESYLGS PQHSPSTRGS PNRSLPSPGV LCGSARPKPY DPPGEKMVAA KVKGEKLDKK LKKMEQNKTA ATRYRQKKRA EQEALTGECK ELEKKNEALK ERADSLAKEI QYLKDLIEEV RKARGKKRVP