Recombinant humaan B7-H3 (4Ig) /B7-H3b-eiwit

CD276, also known as CD276 antigen isoform, is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. It is a costimulatory molecule for T cell activation and IFN-gamma production. It upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu. It is correlated with TNM stage of NSCLC and may serve as a potential biomarker for NSCLC-derived MPEs. Recombinant human CD276, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD276 antigen isoform, CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

48.1 kDa (446aa)

B7-H3 (4Ig), B7-H3b, CD276 antigen isoform, CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, ATGP3635-10 µg, ATGP3635-20 µg, ATGP3635-50 µg, ATGP3635-100 µg, ATGP3635-250 µg, ATGP3635-500 µg, ATGP3635-1 mg, ATGP3635-10, ATGP3635-20, ATGP3635-50, ATGP3635-100, ATGP3635-250, ATGP3635-500, ATGP3635-1

Sun ZZ., et al. (2016) Oncol Rep. 36:231-238.; ; Chen L., et al. (2016) Clin Chim Acta. 457:81-85.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001019907.1

Q5ZPR3

Human

Leu29