Recombinant humaan bèta-2-Microglobuline/B2M-eiwit

Beta2 microglobulin, also known as B2M, is a component of MHC class I molecules, Involved in the presentation of peptide antigens to the immune system. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Increased production or destruction of these cells causes B2M levels in the blood to increase. This increase is seen in people with cancers involving white blood cells, but it is particularly meaningful in people newly diagnosed with multiple myeloma. Multiple myeloma is a malignancy (cancer) of a certain kind of white blood cell, called a plasma cell. B2M Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma or kidney disease. Recombinant B2M protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Beta-2-microglobulin, CDABP0092, HDCMA22P

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

14 kDa (120aa) confirmed by MALDI-TOF

B2-Microglobulin, B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P, ATGP0624-10 µg, ATGP0624-20 µg, ATGP0624-50 µg, ATGP0624-100 µg, ATGP0624-250 µg, ATGP0624-500 µg, ATGP0624-1 mg, ATGP0624-10, ATGP0624-20, ATGP0624-50, ATGP0624-100, ATGP0624-250, ATGP0624-500, ATGP0624-1

Huang WC., et al (2010) J Biol Chem. 285 (11) :7947-56; ; Morabito A., et al. (2009) Hum Immunol. 70 (7) :492-5.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 100 mM NaCl

Cancer

NP_004039.1

P61769

Human

IQRTPKIQV YSRHPAENGK SNFLNCYVSG FHPSDIEVDL LKNGERIEKV EHSDLSFSKD WSFYLLYYTE FTPTEKDEYA CRVNHVTLSQ PKIVKWDRDM