Recombinant humaan bijlagein A5/ANXA5-eiwit

Annexin A5, also known as Annexin V, belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin A5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Recombinant Annexin A5 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Vascular anticoagulant-alpha, VAC-alpha, Thromboplastin inhibitor, PP4, Placental anticoagulant protein I, PAP I, Lipocortin V, ENX2, Endonexin II, CPB-I, Calphobindin I, ANX5, ANX A5, Annexin V, Annexin A5, Annexin 5, Anchorin CII

E.coli

Human

Non-Tagged

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

35.9 kDa (320aa) confirmed by MALDI-TOF

Annexin V, Annexin V, ANX5, ENX2, PP4, Anchorin CII, Annexin 5, Annexin A5, ANX A5, Calphobindin I, Endonexin II, Lipocortin V, PAP I, Placental anticoagulant protein I., ATGP0406-10 µg, ATGP0406-20 µg, ATGP0406-50 µg, ATGP0406-100 µg, ATGP0406-250 µg, ATGP0406-500 µg, ATGP0406-1 mg, ATGP0406-10, ATGP0406-20, ATGP0406-50, ATGP0406-100, ATGP0406-250, ATGP0406-500, ATGP0406-1

Frey B., et al. (2009) J Immunotoxicol. 6 (4) :209-16. ; ; Steele AJ., et al. (2009) Blood. 114 (6) :1217-25.;

Shen MY et al., [Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles. (Diabetes Metab Syndr Obes. 2021) {https://pubmed.ncbi.nlm.nih.gov/34079312/}; ; Sakamoto N et al., Anti-annexin A4 antibody as a biomarker for desquamative interstitial pneumonia. (J Autoimmun. 2025) {https://pubmed.ncbi.nlm.nih.gov/40156961/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Apoptosis

NP_001145.1

P08758

Human

MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI KGDTSGDYKK ALLLLCGEDD