Recombinant humaan BRMS1-eiwit

BRMS1 reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC) . The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. Recombinant human BRMS1 protein, fused to T7-tag at N-terminus, was expressed in E. coli.

Breast cancer metastasis suppressor 1 isoform 1, Breast cancer metastasis suppressor 1, DKFZp564A063

E.coli

Human

T7-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

29.9 kDa (261aa)

BRMS1, Breast cancer metastasis suppressor 1 isoform 1, Breast cancer metastasis suppressor 1, DKFZp564A063, ATGP2502-10 µg, ATGP2502-20 µg, ATGP2502-50 µg, ATGP2502-100 µg, ATGP2502-250 µg, ATGP2502-500 µg, ATGP2502-1 mg, ATGP2502-10, ATGP2502-20, ATGP2502-50, ATGP2502-100, ATGP2502-250, ATGP2502-500, ATGP2502-1

Meehan W.J., et al. (2004) J. Biol. Chem. 279:1562-1569.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Epigenomics (Transcription & Translation)

NP_056214.1

Q9HCU9

Human

MASMTGGQQM GRGSHMPVQP PSKDTEEMEA EGDSAAEMNG EEEESEEERS GSQTESEEES SEMDDEDYER RRSECVSEML DLEKQFSELK EKLFRERLSQ LRLRLEEVGA ERAPEYTEPL GGLQRSLKIR IQVAGIYKGF CLDVIRNKYE CELQGAKQHL ESEKLLLYDT LQGELQERIQ RLEEDRQSLD LSSEWWDDKL HARGSSRSWD SLPPSKRKKA PLVSGPYIVY MLQEIDILED WTAIKKARAA VSPQKRKSDG P