Recombinant humaan C-reactive/CRP-eiwit

CRP, also known as C-reactive protein, is a member of the pentaxin family. This protein is found in the blood, its levels rise dramatically during inflammatory processes occurring in the body. This increment is due to a rise in the plasma concentration of IL-6, which is produced predominantly by macrophages as well as adipocytes. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q. It is also play another important role in innate immunity, as an early defense system against infections. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases. Recombinant human C-Reactive/CRP, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

C-reactive protein, C-reactive protein isoform 1, CRP, PTX1

HEK293

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Absorbance at 280 nm)

> 90% by SDS - PAGE

24.1 kDa (215aa)

, ATGP3993-10 µg, ATGP3993-20 µg, ATGP3993-50 µg, ATGP3993-100 µg, ATGP3993-250 µg, ATGP3993-500 µg, ATGP3993-1 mg, ATGP3993-10, ATGP3993-20, ATGP3993-50, ATGP3993-100, ATGP3993-250, ATGP3993-500, ATGP3993-1

Pepys, MB., et al (2003) J Clin Invest. 111:1805-1812.; ; Danesh, J. et al (2004) N. Engl. J. Med. 350:1387-1397.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction, Metabolism

NP_000558.2

P02741

Human

Asp

QTDMSRK AFVFPKESDT SYVSLKAPLT KPLKAFTVCL HFYTELSSTR GYSIFSYATK RQDNEILIFW SKDIGYSFTV GGSEILFEVP EVTVAPVHIC TSWESASGIV EFWVDGKPRV RKSLKKGYTV GAEASIILGQ EQDSFGGNFE GSQSLVGDIG NVNMWDFVLS PDEINTIYLG GPFSPNVLNW RALKYEVQGE VFTKPQLWP