Recombinant humaan CARD17-eiwit

CARD17 is a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. This protein inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, CARD17 do not induce NF-kappa-B activation. Recombinant human CARD17 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Caspase recruitment domain-containing protein 17, Caspase recruitment domain family, member 17, INCA

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

14.3 kDa (133aa) confirmed by MALDI-TOF

CARD17, Caspase recruitment domain-containing protein 17, Caspase recruitment domain family, member 17, INCA, ATGP2311-10 µg, ATGP2311-20 µg, ATGP2311-50 µg, ATGP2311-100 µg, ATGP2311-250 µg, ATGP2311-500 µg, ATGP2311-1 mg, ATGP2311-10, ATGP2311-20, ATGP2311-50, ATGP2311-100, ATGP2311-250, ATGP2311-500, ATGP2311-1

Lamkanfi M., et al. (2004), Biol. Chem. 279:51729-51738

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT

Apoptosis

NP_001007233

Q5XLA6

Human

MADKVLK EKRKQFIRSV GEGTINGLLG ELLETRVLSQ EEIEIVKCEN ATVMDKARAL LDSVIRKGAP ACQICITYIC EEDSHLAGTL GLSAGPTSGN HLTTQDSQIV LPS