Recombinant humaan Caspase-2-eiwit

CASP2 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. Recombinant human CASP2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Caspase 2 isoform 1, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

14.1 kDa (126aa)

Caspase2, Caspase 2 isoform 1, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, ATGP2688-10 µg, ATGP2688-20 µg, ATGP2688-50 µg, ATGP2688-100 µg, ATGP2688-250 µg, ATGP2688-500 µg, ATGP2688-1 mg, ATGP2688-10, ATGP2688-20, ATGP2688-50, ATGP2688-100, ATGP2688-250, ATGP2688-500, ATGP2688-1

Wang L., Miura M, et al. (1994) Cell 78:739-750; ; Droin N., Beauchemin M., et al. (2000) Cancer Res. 60:7039-7047;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Apoptosis

NP_116764.2

P42575

Human

AGKEKLPKM RLPTRSDMIC GYACLKGTAA MRNTKRGSWY IEALAQVFSE RACDMHVADM LVKVNALIKD REGYAPGTEF HRCKEMSEYC STLCRHLYLF PGHPPT