Recombinant humaan Caspase-3 eiwit

CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Recombinant human CASP3 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Caspase 3, CPP32, CPP32B, SCA-1

E.coli

Human

Non-Tagged

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

12 kDa (103aa)

Caspase3, Caspase 3, CPP32, CPP32B, SCA-1, ATGP2651-10 µg, ATGP2651-20 µg, ATGP2651-50 µg, ATGP2651-100 µg, ATGP2651-250 µg, ATGP2651-500 µg, ATGP2651-1 mg, ATGP2651-10, ATGP2651-20, ATGP2651-50, ATGP2651-100, ATGP2651-250, ATGP2651-500, ATGP2651-1

Harrington HA, Ho KL, et al. (2008) . Theor Biol Med Model. 10; ;5:26.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Apoptosis

NP_116786

P42574

Human

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