Recombinant humaan CCL28/MEC-eiwit

CCL28, also known as chemokine (C-C motif) ligand 28 or mucosae-associated epithelial chemokine (MEC), belongs to the subfamily of small cytokine CC proteins. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3. This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury. Recombinant CCL28 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

C-C motif chemokine ligand 28, Mucosae-associated epithelial chemokine, MEC, Protein CCK1, Small-inducible cytokine A28, SCYA28, CCK1

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

14.3 kDa (126aa) confirmed by MALDI-TOF

CCL28, Chemokine (C-C motif) ligand 28, CCK1, MEC, SCYA28, Chemokine (C-C motif) ligand 28, CCL28, CC chemokine CCL28, mucosae-associated epithelial chemokine, small inducible cytokine subfamily A (Cys-Cys) member 28, small inducible cytokine A28, ATGP0387-10 µg, ATGP0387-20 µg, ATGP0387-50 µg, ATGP0387-100 µg, ATGP0387-250 µg, ATGP0387-500 µg, ATGP0387-1 mg, ATGP0387-10, ATGP0387-20, ATGP0387-50, ATGP0387-100, ATGP0387-250, ATGP0387-500, ATGP0387-1

Pacheco-Rodriguez G., et al. (2009) J Immunol. 182 (3) :1270-7. ; ; Sundstrom P., et al. (2008) Eur J Immunol. 38 (12) :3327-38.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol

Hormones & Cytokines

NP_683513

Q9NRJ3

Human

MGSSHHHHHH SSGLVPRGSH MILPIASSCC TEVSHHISRR LLERVNMCRI QRADGDCDLA AVILHVKRRR ICVSPHNHTV KQWMKVQAAK KNGKGNVCHR KKHHGKRNSN RAHQGKHETY GHKTPY