Recombinant humaan CCND2-eiwit

CCND2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. High level expression of this protein was observed in ovarian and testicular tumors. Recombinant human CCND2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Cyclin D2, KIAK0002, MGC102758, G1/S-specific cyclin-D2

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

35.6 kDa (313aa)

CCND2, Cyclin D2, KIAK0002, MGC102758, G1/S-specific cyclin-D2, ATGP1342-10 µg, ATGP1342-20 µg, ATGP1342-50 µg, ATGP1342-100 µg, ATGP1342-250 µg, ATGP1342-500 µg, ATGP1342-1 mg, ATGP1342-10, ATGP1342-20, ATGP1342-50, ATGP1342-100, ATGP1342-250, ATGP1342-500, ATGP1342-1

Inaba T., et al. (1992) Genomics. 13 (3) :565-74.; ; Wang Z., et al. (2008) Cell Struct Funct. 33 (2) :171-83.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 1M urea.

Cancer

NP_001750

P30279

Human

MGSSHHHHHH SSGLVPRGSH MGSHMELLCH EVDPVRRAVR DRNLLRDDRV LQNLLTIEER YLPQCSYFKC VQKDIQPYMR RMVATWMLEV CEEQKCEEEV FPLAMNYLDR FLAGVPTPKS HLQLLGAVCM FLASKLKETS PLTAEKLCIY TDNSIKPQEL LEWELVVLGK LKWNLAAVTP HDFIEHILRK LPQQREKLSL IRKHAQTFIA LCATDFKFAM YPPSMIATGS VGAAICGLQQ DEEVSSLTCD ALTELLAKIT NTDVDCLKAC QEQIEAVLLN SLQQYRQDQR DGSKSEDELD QASTPTDVRD IDL