Recombinant humaan CD107b/LAMP2-eiwit

LAMP2, also known as lysosome-associated membrane glycoprotein 2 isoform A, is a major component of lysosomal membranes. It provides selectins with carbohydrate ligands. This protein mediates the lysosomal uptake of the chaperone HSC73 in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles. Deficiency of LAMP2 is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. Recombinant human LAMP2 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, CD107b, Lysosomal membrane glycoprotein type B, LGP-B

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

39.4 kDa (356aa)

Lysosome-associated membrane protein 2, Lysosome-associated membrane glycoprotein 2 isoform A, Lysosome-associated membrane glycoprotein 2, Lysosome associated membrane protein 2, Lysosome associated membrane glycoprotein 2 isoform A, Lysosome associated membrane glycoprotein 2, Lysosomal membrane glycoprotein type B, LGP-B, LGPB, LGP-96, LGP96, LGP-110, LGP110, LGP B, LGP 96, LGP 110, LAMP-B, LAMPB, LAMP-2, LAMP2, LAMP B, LAMP 2, CD107b, CD107 antigen-like family member B, CD107 antigen like family member B, ATGP3680-10 µg, ATGP3680-20 µg, ATGP3680-50 µg, ATGP3680-100 µg, ATGP3680-250 µg, ATGP3680-500 µg, ATGP3680-1 mg, ATGP3680-010, ATGP3680-020, ATGP3680-050, ATGP3680-100, ATGP3680-250, ATGP3680-500, ATGP3680-01M

Mello AS., et al, (2014) Mol Cell Biochem. 385:1-6.; ; Damaghi M., et al, (2015) Nat Commun. 6:8752.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_002285

P13473

Human

Ala

ADPLELNLTD SENATCLYAK WQMNFTVRYE TTNKTYKTVT ISDHGTVTYN GSICGDDQNG PKIAVQFGPG FSWIANFTKA ASTYSIDSVS FSYNTGDNTT FPDAEDKGIL TVDELLAIRI PLNDLFRCNS LSTLEKNDVV QHYWDVLVQA FVQNGTVSTN EFLCDKDKTS TVAPTIHTTV PSPTTTPTPK EKPEAGTYSV NNGNDTCLLA TMGLQLNITQ DKVASVININ PNTTHSTGSC RSHTALLRLN SSTIKYLDFV FAVKNENRFY LKEVNISMYL VNGSVFSIAN NNLSYWDAPL GSSYMCNKEQ TVSVSGAFQI NTFDLRVQPF NVTQGKYSTA QDCSADDDNF HHHHHH