Recombinant humaan CD117/c-kit eiwit

KIT, also known as mast/stem cell growth factor receptor Kit isoform 1, is a cytokine receptor that is expressed not only in hematopoietic stem cells but also in other cell types. It binds to receptor tyrosine kinase type III, a stem cell factor, also called a rigid factor or c-kit ligand. When this receptor binds to stem cell factor (SCF), it forms a dimer that activates intrinsic tyrosine kinase activity, which, in turn, phosphorylates and activates signaling molecules that propagate signals in cells. This receptor protects vascular smooth muscle cells from apoptosis and helps restore cardiac function after myocardial infarction. Recombinant human KIT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Mast/stem cell growth factor receptor Kit isoform 1, KIT, C-Kit, CD117, PBT, SCFR

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

57.1 kDa (507aa)

CD117, c-kit, Mast/stem cell growth factor receptor Kit isoform 1, KIT, C-Kit, CD117, PBT, SCFR, ATGP3665-10 µg, ATGP3665-20 µg, ATGP3665-50 µg, ATGP3665-100 µg, ATGP3665-250 µg, ATGP3665-500 µg, ATGP3665-1 mg, ATGP3665-10, ATGP3665-20, ATGP3665-50, ATGP3665-100, ATGP3665-250, ATGP3665-500, ATGP3665-1

Yarden Y., et al. (1987) EMBO J. 6:3341-3451.; ; Anzai N., et al. (2002) Blood. 99:4413-4421.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_000213.1

P10721

Human

Gln26