Recombinant humaan CD155/PVR-eiwit

PVR, also known as poliovirus receptor isoform alpha, is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. It catalyzes a large structural change in the virus that exposes membrane-binding protein chains. It plays an important regulatory role in helper T cell differentiation and allergic diseases. It is expressed in many types of human cells and has diverse functions. It may be potentially useful as a biomarker for cancer development and progression. It may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer. Recombinant human PVR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poliovirus receptor isoform alpha, PVR, CD155, HVED, Necl-5, NECL5, PVS, TAGE4, PVR cell adhesion molecule, Nectin-like protein 5

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

36.1 kDa (331aa)

PVR, Poliovirus receptor isoform alpha, PVR, CD155, HVED, Necl-5, NECL5, PVS, TAGE4, ATGP3644-10 µg, ATGP3644-20 µg, ATGP3644-50 µg, ATGP3644-100 µg, ATGP3644-250 µg, ATGP3644-500 µg, ATGP3644-1 mg, ATGP3644-10, ATGP3644-20, ATGP3644-50, ATGP3644-100, ATGP3644-250, ATGP3644-500, ATGP3644-1

Nishiwada S., et al. (2015) Anticancer Res. 35:2287-2297.; ; Strauss M., et al. (2015) J Virol. 89:4143-4157.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_006496

P15151

Human

Trp21

WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGM SRNLEHHHHH H