Recombinant humaan CD160 eiwit

CD160, also known as CD160 antigen, is a human natural killer (NK) -cell-activating receptor that is also expressed on T-cell subsets. It is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease. It was identified as a T cell coinhibitory molecule that interacts with the herpesvirus entry mediator (HVEM) on antigen-presenting cells to deliver a potent inhibitory signal to CD4 (+) T cells. Recombinant human CD160, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD160 antigen, CD160, BY55, NK1, NK28

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

15.9 kDa (142aa)

CD160, CD160 antigen, CD160, BY55, NK1, NK28, ATGP3576-10 µg, ATGP3576-20 µg, ATGP3576-50 µg, ATGP3576-100 µg, ATGP3576-250 µg, ATGP3576-500 µg, ATGP3576-1 mg, ATGP3576-10, ATGP3576-20, ATGP3576-50, ATGP3576-100, ATGP3576-250, ATGP3576-500, ATGP3576-1

Farren TW., et al. (2011) Blood. 118:2174-2183.; ; Kojima R., et al. (2011) J Mol Biol. 413:762-772.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_008984.1

O95971

Human

Ala

INITSSA SQEGTRLNLI CTVWHKKEEA EGFVVFLCKD RSGDCSPETS LKQLRLKRDP GIDGVGEISS QLMFTISQVT PLHSGTYQCC ARSQKSGIRL QGHFFSILFT ETGNYTVTGL KQRQHLEFSH NEGTLS