Recombinant humaan CD161/KLRB1-eiwit

Killer cell lectin-like receptor subfamily B member 1, also known as KLRB1, plays an inhibitory role on natural killer (NK) cells cytotoxicity. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. Recombinant human KLRB1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Killer cell lectin like receptor B1, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161, CLEC5B, NKRP1A, NKR-P1

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

21.0 kDa (183aa)

CD161, Killer cell lectin-like receptor subfamily B member 1, p35-2, STX4A, ATGP1678-10 µg, ATGP1678-20 µg, ATGP1678-50 µg, ATGP1678-100 µg, ATGP1678-250 µg, ATGP1678-500 µg, ATGP1678-1 mg, ATGP1678-10, ATGP1678-20, ATGP1678-50, ATGP1678-100, ATGP1678-250, ATGP1678-500, ATGP1678-1

Lanier L.L., et al. (1994) J. Immunol. 153:2417-2428; ; Christiansen D., et al. (2006) Xenotransplantation. 13:440-446

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Immunology

NP_002249

Q12918

Human

QKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS