Recombinant humaan CD161/KLRB1-eiwit

KLRB1, also known as killer cell lectin-like receptor subfamily B member 1, is classified as a type II membrane protein because it has an external C terminus. It is expressed by NK cells and may be involved in the regulation of NK cell function. It plays a novel and important role in B cell maturation within the GC in humans. It is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T helper 17 (Th17) cells, and a population of unconventional T cells known as mucosal-associated invariant T (MAIT) cells. It is also expressed, at intermediate levels, on a prominent subset of polyclonal CD8+ T cells, including antiviral populations that display a memory phenotype. Recombinant human KLRB1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Killer cell lectin like receptor B1, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161, CLEC5B, NKRP1A, NKR-P1

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

45.7 kDa (401aa)

CD161, Killer cell lectin-like receptor subfamily B member 1, KLRB1, CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A, NKRP1A, ATGP3675-10 µg, ATGP3675-20 µg, ATGP3675-50 µg, ATGP3675-100 µg, ATGP3675-250 µg, ATGP3675-500 µg, ATGP3675-1 mg, ATGP3675-10, ATGP3675-20, ATGP3675-50, ATGP3675-100, ATGP3675-250, ATGP3675-500, ATGP3675-1

Fergusson JR., et al. (2016) Mucosal Immunol. 9:401-413.; ; Llibre A1., et al. (2016) J Immunol. 196:2085-2094.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_002249.1

Q12918

Human

Ala

QKSSIEK CSVDIQQSRN KTTERPGLLN CPIYWQQLRE KCLLFSHTVN PWNNSLADCS TKESSLLLIR DKDELIHTQN LIRDKAILFW IGLNFSLSEK NWKWINGSFL NSNDLEIRGD AKENSCISIS QTSVYSEYCS TEIRWICQKE LTPVRNKVYP DS