Recombinant humaan CD19-eiwit

CD19, also known as B-lymphocyte antigen CD19 isoform 1, is a member of the Ig superfamily expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells. It has been implicated as a signal-transducing receptor in the control of proliferation and differentiation. It acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies. Recombinant human CD19, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

B-lymphocyte antigen CD19 isoform 1, CD19, B4, CVID3

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

57 kDa (510aa)

CD19, B-lymphocyte antigen CD19 isoform 1, CD19, B4, CVID3, ATGP3816-10 µg, ATGP3816-20 µg, ATGP3816-50 µg, ATGP3816-100 µg, ATGP3816-250 µg, ATGP3816-500 µg, ATGP3816-1 mg, ATGP3816-10, ATGP3816-20, ATGP3816-50, ATGP3816-100, ATGP3816-250, ATGP3816-500, ATGP3816-1

Bradbury LE., et al. (1992) J Immunol. 149:2841-2850.; ; Kozmik Z., et al. (1992) Mol Cell Biol. 12:2662-2672.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001171569.1

P15391

Human

Glu21