Recombinant humaan CD28-eiwit

CD28, also known as T-cell-specific surface glycoprotein CD28 isoform 1, is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular) . CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the up-regulation of bcl-XL. It ligation has also been shown to regulate Th1/Th2 differentiation. Recombinant human CD28, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

T-cell-specific surface glycoprotein CD28 isoform 1, CD28, Tp44

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE, Bioactivity

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

42.4 kDa (376aa)

CD28, ATGP3603-10 µg, ATGP3603-20 µg, ATGP3603-50 µg, ATGP3603-100 µg, ATGP3603-250 µg, ATGP3603-500 µg, ATGP3603-1 mg, ATGP3603-10, ATGP3603-20, ATGP3603-50, ATGP3603-100, ATGP3603-250, ATGP3603-500, ATGP3603-1

Prasad KV., et al. (1994) National Academy. 91: 2834 -2838.; ; Okkenhaug K., et al. (1998) J. Biol. Chem. 273: 21194 -21202.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_006130.1

P10747

Human

Ala

NKILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKP